منابع مشابه
MicroRNAs involved in the regulation of postischemic cardiac fibrosis.
A s deaths from acute myocardial infarction have declined dramatically over the past several decades, more and more patients survive with chronic myocardial ischemia. Hearts of most patients who survive acute myocardial infarction undergo remodeling. Hearts of most patients with sustained hyperten-sion, another common cardiovascular disease, also show some degree of remodeling. The heart consis...
متن کاملModulating microRNAs as Novel Therapeutic Targets in Cardiac Fibrosis
This commentary highlights the findings by Tao et al. (Theranostics 2016; 6: 2068-2083) that targeting miR-433 may be a potential therapeutic strategy for myocardial fibrosis and subsequently discusses the obstacles and prospects associated with the application of therapeutic microRNAs in anti-fibrosis treatment.
متن کاملOverview of MicroRNAs in Cardiac Hypertrophy, Fibrosis, and Apoptosis
MicroRNAs (miRNAs) are non-coding RNAs that play essential roles in modulating the gene expression in almost all biological events. In the past decade, the involvement of miRNAs in various cardiovascular disorders has been explored in numerous in vitro and in vivo studies. In this paper, studies focused upon the discovery of miRNAs, their target genes, and functionality are reviewed. The select...
متن کاملControl of cardiac excitability by microRNAs.
Cardiovascular disease is the leading cause of morbidity and mortality in developed countries. The pathological process of the heart is associated with an altered expression profile of genes that are important for cardiac function. MicroRNAs (miRNAs) have recently emerged as one of the central players of gene expression regulation. The implications of miRNAs in the pathological process of the c...
متن کاملRegulation of cardiac microRNAs by cardiac microRNAs.
RATIONALE MicroRNAs modestly suppress their direct mRNA targets, and these direct effects are amplified by modulation of gene transcription pathways. Consequently, indirect mRNA modulatory effects of microRNAs to increase or decrease mRNAs greatly outnumber direct target suppressions. Because microRNAs are products of transcription, the potential exists for microRNAs that regulate transcription...
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ژورنال
عنوان ژورنال: Heart
سال: 2012
ISSN: 1355-6037,1468-201X
DOI: 10.1136/heartjnl-2012-302920a.64